清华麦戈文脑科学讲座系列：Dr. Yu Fu讲座

2018年10月18日 10:00-11:30

清华大学生物新馆143

报告人

Dr. Yu Fu

Singapore Bioimaging Consortium Agency for Science, Technology and Research (A*STAR)

主持人

Dr. Kexin Yuan

题目

Feeding regulation by tuberal nucleus somatostatin neurons

摘要

 The tuberal nucleus (TN) is a surprisingly understudied brain region. We found that somatostatin (SST) neurons in TN, which is known to exhibit pathological or cytological changes in human neurodegenerative diseases, play a crucial role in regulating feeding in mice. GABAergic tuberal SST (TNSST) neurons were activated by hunger and hunger hormone ghrelin. Activation of TNSST neurons promoted feeding while inhibition reduced it via projections to the paraventricular nucleus and bed nucleus of the stria terminalis. Ablation of TNSST neurons reduced body weight gain and food intake. These findings reveal a new feeding regulation mechanism through orexigenic TNSST neurons, and provide a new perspective for understanding appetite changes.

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